What features do cells show when they undergo ferroptosis?

Ferroptosis is a type of regulated cell death that results when lipid peroxides accumulate on cell membranes at toxic levels causing oxidative damage to cell membranes. Cells that undergo ferroptosis show a combination of morphological and biochemical features. 

Morphological features that cells exhibit when they undergo ferroptosis include:

• Rupture of cell membrane rupture
• Swelling of cytoplasmic organelles
• Mitochondrial shrinkage with increased density of mitochondrial membrane
• Reduction or absence of mitochondrial cristae
• Rupture of outer mitochondrial membrane
• Moderate chromatin condensation

Biochemical features that cells exhibit when they undergo ferroptosis include:

• Excessive accumulation of iron 
• Lipid peroxidation and toxic buildup of lipid peroxides on cell membrane