What are the applications of ferritinophagy?

Ferritinophagy offers a novel strategy for cancer therapy by inducing ferroptosis that degrades ferritin, leading to lipid peroxidation and cell death. 

Ferritinophagy affects the lipid peroxidation pathway and inhibits Epithelial-Mesenchymal Transition (EMT), which is crucial in promoting cell death and preventing cancer metastasis.

Ferrintophagy-induced cell deaths release signaling molecules such as proteoglycan decorin, which activates innate and adaptive immune responses against tumors. It also releases inflammatory factors such as interleukin-6 (IL-6) and tumor necrosis factor. 

Ferritinophagy helps maintain intracellular iron balance, which is essential in preventing diseases related to iron metabolism dysfunction.