What are the main characteristics of ferroptosis?

Ferroptosis is a novel type of regulated cell death. Main characteristics of ferroptosis that differentiate it from other forms of cell death include: 

• Imbalance between the production and degradation of intracellular lipid and Reactive Oxygen Species (ROS)
• Elevated levels of intracellular iron and ROS
• Decreased levels of antioxidants, which leads to oxidative cell death
• Mitochondria appear smaller than normal and have condensed mitochondrial membrane densities and ruptured outer mitochondrial membrane
• Mitochondrial cristae are reduced or absent
• Nucleus lack chromatin condensation although it retains its normal size
• Cell membrane is ruptured and blebbed