How is ferroptosis different from other forms of cell death?

The different forms of cell death other than ferroptosis include apoptosis, necroptosis, and autophagy. Ferroptosis is distinct from other forms of cell death in several ways. 

Biochemical Features

• Ferroptosis: Characterized by iron accumulation and lipid peroxidation, leading to damage from iron-dependent reactive oxygen species (ROS).
• Apoptosis: Characterized by activation of Caspase pathway, DNA fragmentation, and degradation of mitochondrial transmembrane potential protein
• Autophagy: Marked by the presence of autophagosomes, increased lysosomal activity and autophagic flux, and degradation of cytoplasmic components, 
• Necrosis: Is an unregulated form of cell death and is associated with ATP depletion, hyperactivation of PARP1, and release of damage-associated molecular patterns (DAMPs).
• Necroptosis: Involves a fatal influx of Ca2+ and the formation of the RIPK1-RIPK3-MLKL complex.
• Pyroptosis: Is caspase-dependent and features formation of inflammasomes and the release of proinflammatory factors.

Morphological Features

• Ferroptosis: Cells have shrunken mitochondria with reduced or absent mitochondrial cristae, higher membrane densities, and ruptured outer mitochondrial membranes.
• Apoptosis: Cells become shrunken and round with a contracted, invaginated cell membrane, nucleus is condensed and fragmented, and apoptotic bodies are present. Mitochondrial structure remains relatively unaltered with no significant changes. 
• Autophagy: Involves formation of double-membraned autolysosomes. Displays intact cell membranes with visible autophagosomes and degraded organelles.
• Necrosis: Characterized by ruptured cell membranes, swollen cells and organelles, damaged mitochondria, degraded nuclear chromosome, and cell lysis. 
• Necroptosis: Shows generalized swelling of cytoplasm and organelles, ruptured cell membranes with spillage of cellular constituents, and moderate chromatin condensation. 
• Pyroptosis: Shows cytoplasmic swelling, fragmented chromatin, shrunken but intact nuclei, and rupture of cell membrane. Mitochondria are intact and swollen with lower matrix density and collapsed cristae.