What are the mechanisms of ferroptosis?

Ferroptosis is a type of regulated cell death. It is triggered by two main factors. The first is the oxidation of specific liquids or lipid peroxidation. The second is damage to natural mechanisms that hinder the accumulation of these oxidized lipids. Both these factors result in toxic buildup of lipid peroxides on cell membranes, which lead to oxidative damage to cell membranes. Iron plays a critical role in this cell death process by catalyzing ROS formation. 

Ferroptosis causes several morphological, biochemical, and genetic changes including swelling of cytoplasmic organelles, loss of plasma membrane integrity, chromatin condensation, shrunken mitochondria, and overexpression of some genes and proteins.