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Z-IETD-aminoluciferin
Z-IETD-aminoluciferin is a luminogenic substrate that measures caspase-6 and granzyme B activities in apoptotic cells. Caspases, a family of aspartate-specific cysteine proteases, are key regulators of apoptosis, orchestrating the initiation and execution of cellular disassembly through the cleavage of specific cellular proteins. The tetrapeptide sequence IETD in this substrate is specific for protease cleavage by caspase-6. Following caspase-6 activation, the IETD peptide is cleaved just after the aspartic acid residue (D), releasing aminoluciferin, which serves as a luminescent substrate for the luciferase reaction. The intensity of the bioluminescent signal is directly proportional to the amount of caspase-6 activity in the sample, making it a valuable tool for researchers to study and quantify apoptotic processes, screen potential drug candidates, and investigate various cellular pathways related to cell death and survival.
Spectrum
Product family
| Name | Excitation (nm) | Emission (nm) | Extinction coefficient (cm -1 M -1) |
| Z-IETD-AFC *CAS 219138-02-0* | 376 | 482 | 170001 |
| Z-DEVD-aminoluciferin | 362 | 499 | 18000 |
| Z-LETD-aminoluciferin | 362 | 499 | 18000 |
| Z-LEHD-aminoluciferin | 362 | 499 | 18000 |
| Z-VDVAD-aminoluciferin | 362 | 499 | 18000 |
| Z-VEID-aminoluciferin | 362 | 499 | 18000 |
| Z-ATAD-aminoluciferin | 362 | 499 | 18000 |
References
View all 50 references: Citation Explorer
Spinal Caspase-6 Contributes to Intrathecal Morphine-induced Acute Itch and Contact Dermatitis-induced Chronic Itch Through Regulating the Phosphorylation of Protein Kinase Mζ in Mice.
Authors: Pei, Xuxing and Li, Bing and Xu, Xiaodong and Zhang, Hui
Journal: Neuroscience (2024): 21-34
Authors: Pei, Xuxing and Li, Bing and Xu, Xiaodong and Zhang, Hui
Journal: Neuroscience (2024): 21-34
Antisense oligonucleotide-mediated disruption of HTT caspase-6 cleavage site ameliorates the phenotype of YAC128 Huntington disease mice.
Authors: Kuijper, Elsa C and Overzier, Maurice and Suidgeest, Ernst and Dzyubachyk, Oleh and Maguin, Cécile and Pérot, Jean-Baptiste and Flament, Julien and Ariyurek, Yavuz and Mei, Hailiang and Buijsen, Ronald A M and van der Weerd, Louise and van Roon-Mom, Willeke
Journal: Neurobiology of disease (2024): 106368
Authors: Kuijper, Elsa C and Overzier, Maurice and Suidgeest, Ernst and Dzyubachyk, Oleh and Maguin, Cécile and Pérot, Jean-Baptiste and Flament, Julien and Ariyurek, Yavuz and Mei, Hailiang and Buijsen, Ronald A M and van der Weerd, Louise and van Roon-Mom, Willeke
Journal: Neurobiology of disease (2024): 106368
NUAK1 promotes metabolic dysfunction-associated steatohepatitis progression by activating Caspase 6-driven pyroptosis and inflammation.
Authors: Sheng, Mingwei and Huo, Shuhan and Jia, Lili and Weng, Yiqi and Liu, Weihua and Lin, Yuanbang and Yu, Wenli
Journal: Hepatology communications (2024)
Authors: Sheng, Mingwei and Huo, Shuhan and Jia, Lili and Weng, Yiqi and Liu, Weihua and Lin, Yuanbang and Yu, Wenli
Journal: Hepatology communications (2024)
Caspase 6 promotes innate immune activation by functional crosstalk between RIPK1-IκBα axis in liver inflammation.
Authors: Lin, Yuanbang and Sheng, Mingwei and Qin, Hua and Zhang, Peng and Wang, Chunli and Fu, Wei and Meng, Xiangjun and Wang, Duowei and Hou, Yachao
Journal: Cell communication and signaling : CCS (2023): 282
Authors: Lin, Yuanbang and Sheng, Mingwei and Qin, Hua and Zhang, Peng and Wang, Chunli and Fu, Wei and Meng, Xiangjun and Wang, Duowei and Hou, Yachao
Journal: Cell communication and signaling : CCS (2023): 282
Royal jelly protects brain tissue against fluoride-induced damage by activating Bcl-2/NF-κB/caspase-3/caspase-6/Bax and Erk signaling pathways in rats.
Authors: Aslan, Abdullah and Beyaz, Seda and Gok, Ozlem and Parlak, Gozde and Can, Muhammed Ismail and Agca, Can Ali and Ozercan, Ibrahim Hanifi and Parlak, Akif Evren
Journal: Environmental science and pollution research international (2023): 49014-49025
Authors: Aslan, Abdullah and Beyaz, Seda and Gok, Ozlem and Parlak, Gozde and Can, Muhammed Ismail and Agca, Can Ali and Ozercan, Ibrahim Hanifi and Parlak, Akif Evren
Journal: Environmental science and pollution research international (2023): 49014-49025
Page updated on November 21, 2024
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