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Ac-DEVD-aminoluciferin
Ac-DEVD-aminoluciferin is a luminogenic substrate that measures caspase-3 and -7 activities in apoptotic cells. Caspases, a family of aspartate-specific cysteine proteases, are key regulators of apoptosis, orchestrating the initiation and execution of cellular disassembly through the cleavage of specific cellular proteins. Notably, caspases-3 and -7, target the DEVD motif in poly(ADP-ribose) polymerase (PARP), disrupting the repair capabilities of PARP and facilitating DNA fragmentation, a hallmark of apoptosis. When caspase-3/7 enzymes cleave the Ac-DEVD-aminoluciferin substrate, it releases aminoluciferin, which can react with luciferase to produce bioluminescence. The intensity of the bioluminescent signal is directly proportional to the amount of caspase-3/7 activity in the sample, making it a valuable tool for researchers to study and quantify apoptotic processes, screen potential drug candidates, and investigate various cellular pathways related to cell death and survival.
Spectrum
Product family
| Name | Excitation (nm) | Emission (nm) |
| Ac-DEVD-AFC *CAS 201608-14-2* | 376 | 482 |
| Ac-DEVD-AMC *CAS 169332-61-0* | 341 | 441 |
| Z-DEVD-aminoluciferin | 362 | 499 |
References
View all 22 references: Citation Explorer
Validation and application of caged Z-DEVD-aminoluciferin bioluminescence for assessment of apoptosis of wild type and TLR2-deficient mice after ischemic stroke.
Authors: Josić Dominović, P and Dobrivojević Radmilović, M and Srakočić, S and Mišerić, I and Škokić, S and Gajović, S
Journal: Journal of photochemistry and photobiology. B, Biology (2024): 112871
Authors: Josić Dominović, P and Dobrivojević Radmilović, M and Srakočić, S and Mišerić, I and Škokić, S and Gajović, S
Journal: Journal of photochemistry and photobiology. B, Biology (2024): 112871
[Tetrahydropalmatine inhibiting mitophagy through ULK1/FUNDC1 pathway to alleviate hypoxia/reoxygenation injury in H9c2 cells].
Authors: Xin, Gao-Jie and Liu, Zi-Xin and Chen, Yuan-Yuan and Zhang, Hui-Yu and Guo, Fan and Peng, Han and Li, Lei and Han, Xiao and Liu, Jian-Xun and Fu, Jian-Hua
Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica (2024): 1286-1294
Authors: Xin, Gao-Jie and Liu, Zi-Xin and Chen, Yuan-Yuan and Zhang, Hui-Yu and Guo, Fan and Peng, Han and Li, Lei and Han, Xiao and Liu, Jian-Xun and Fu, Jian-Hua
Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica (2024): 1286-1294
Pharmacological anti-tumor effects of natural Chamaecyparis obtusa (siebold & zucc.) endl. Leaf extracts on breast cancer.
Authors: Kwon, Yong-Jin and Seo, Eun-Bi and Kim, Seul-Ki and Lee, Hyun-Seung and Lee, Haeri and Jang, Young-Ah and Kim, Yu Mi and Kim, Yong-Nyun and Lee, Jin-Tae and Ye, Sang-Kyu
Journal: Journal of ethnopharmacology (2023): 116598
Authors: Kwon, Yong-Jin and Seo, Eun-Bi and Kim, Seul-Ki and Lee, Hyun-Seung and Lee, Haeri and Jang, Young-Ah and Kim, Yu Mi and Kim, Yong-Nyun and Lee, Jin-Tae and Ye, Sang-Kyu
Journal: Journal of ethnopharmacology (2023): 116598
Effects of circRNA_103993 on the proliferation and apoptosis of NSCLC cells through miR-1271/ERG signaling pathway.
Authors: Lv, Y-S and Wang, C and Li, L-X and Han, S and Li, Y
Journal: European review for medical and pharmacological sciences (2020): 8384-8393
Authors: Lv, Y-S and Wang, C and Li, L-X and Han, S and Li, Y
Journal: European review for medical and pharmacological sciences (2020): 8384-8393
Tlr2 Deficiency is Associated with Enhanced Elements of Neuronal Repair and Caspase 3 Activation Following Brain Ischemia.
Authors: Gorup, Dunja and Škokić, Siniša and Kriz, Jasna and Gajović, Srećko
Journal: Scientific reports (2019): 2821
Authors: Gorup, Dunja and Škokić, Siniša and Kriz, Jasna and Gajović, Srećko
Journal: Scientific reports (2019): 2821
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