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AAT Bioquest

What is the structure of CD34?

Posted November 23, 2022


Answer

CD34 is a 105-120 kDa, type I monomeric glycophosphoprotein and member of the sialomucin protein family. It is made up of a highly conserved cytoplasmic domain and transmembrane domain that is characterized by a heavily glycosylated N-terminal region and a well conserved C-terminal region. The N-terminal region plays a key role in determining interactions between CD34 with different ligands including E- and L-selectins.

Additional resources

CD34 (Mucosialin)

FITC Anti-human CD34 Antibody *4H11*

Purified Anti-human CD34 Antibody *4H11*

Three-dimensional structure prediction of the interaction of CD34 with the SH3 domain of Crk-L