How can one distinguish naive from effector/effector memory CD8 T cells?

Posted May 9, 2020

Antibodies and Proteomics

Antibody and Protein Labeling

Cluster of Differentiation (CD Antibodies)

Immunohistochemistry (IHC)

Answer

Naive CD8 T cells are CD44 low and CD62L positive, while effector/effector memory CD8 T cells are CD44 high and CD62L negative.

Additional resources

Sckisel, G. D., Mirsoian, A., Minnar, C. M., Crittenden, M., Curti, B., Chen, J. Q., ... & Murphy, W. J. (2017). Differential phenotypes of memory CD4 and CD8 T cells in the spleen and peripheral tissues following immunostimulatory therapy. Journal for immunotherapy of cancer, 5(1), 33.

Cluster of Differentiation (CD Antibodies)

CD8 Infographic

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