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AAT Bioquest

What is the structure of CD19?

Posted November 23, 2022


Answer

CD19 is a type I one-pass transmembrane protein and a biomarker for B cells and follicular dendritic cells. It has a single transmembrane domain, an extracellular N-terminus, and a cytoplasmic C-terminus. The highly conserved, 242 amino acid cytoplasmic domain includes several tyrosine residues, a small helical non-Ig domain with possible disulfide links separating the two extracellular C2 Ig-like domains. 

Additional resources

CD19 (Leu12, B-Lymphocyte Antigen B4)

Purified Anti-human CD19 Antibody *HIB19*

PacBlue Anti-human CD19 Antibody *HI19a*

Cryo-EM structure of the B cell co-receptor CD19 bound to the tetraspanin CD81