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AAT Bioquest

What happens to mRNA after processing is complete?

Posted April 27, 2023


Answer

mRNAs move to cytoplasm where they go through translation. mRNA is not meant to store information for the long term. After processing is complete and protein is synthesized, mRNA used in translation is degraded by exonucleases that shorten the poly-A tail. When the tail is short enough, degradation enzymes break it apart into reusable parts, which are retained in the cell to be reused, and unusable parts, which are eliminated from the cell.

Additional resources

When mRNA translation meets decay

Antibody and Protein Labeling

Transfectamine™ mRNA Transfection Reagent