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AAT Bioquest

Are mRNAs found in prokaryotes differ from those of eukaryotes?

Posted April 27, 2023


Answer

Yes, mRNAs found in prokaryotes differ from those of eukaryotes in a number of ways. Here’s a look at the differences between prokaryotic mRNA and eukaryotic mRNA: 

Prokaryotic mRNA:

  • Is synthesized in the cytoplasm by the transcription of operons
  • Is polycistronic (codes for more than one protein)
  • Transcription is coupled with translation 
  • Does not contain both 5′ cap and 3′ tail
  • Has a very short lifespan and undergoes very little modifications after transcription

Eukaryotic mRNA:

  • Is synthesized in the nucleus by the transcription of single genes
  • Is monocistronic (codes for a single protein)
  • Translation occurs only after transcription is complete
  • Contains both 5′ cap and 3′ tail
  • Has a relatively long and stable lifespan and undergoes major modifications after transcription
Additional resources

Engineering circular RNA for potent and stable translation in eukaryotic cells

Antibody and Protein Labeling

Transfectamine™ mRNA Transfection Reagent

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