What are the functions of CD19?
Posted November 23, 2022
Answer
CD19 is a B-cell-restricted signaling molecule. It modulates both BCR-dependent and BCR-independent signaling, thereby establishing inherent B cell signaling thresholds. Lack of CD19 results in faulty BCR (B cell receptor) signaling. CD19 plays an essential role in B cell development and maturation, antigen-independent development, and immunoglobulin-induced activation of B cells. The body also needs CD19 to mount an optimal immune response.
Additional resources
CD19 (Leu12, B-Lymphocyte Antigen B4)
PacBlue Anti-human CD19 Antibody *HI19a*