How is mitochondrial morphology regulated?

Mitochondrial morphology is regulated by the rates of fission and fusion. Fusion refers to the merging of two mitochondria into a single organelle. The process is primarily regulated by mitofusins. Fission involves the division of a single mitochondrion into two separate organelles. The two proteins which facilitate this process are Fis1 and Drp1. Additionally, modifications occurring after protein synthesis such as ubiquitination, sumoylation, and phosphorylation are believed to regulate both the fusion and division processes of the mitochondrial network.