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Z-VEID-aminoluciferin
Z-VEID-aminoluciferin is a luminogenic substrate that measures caspase-6 activity in apoptotic cells. Caspases, a family of aspartate-specific cysteine proteases, are key regulators of apoptosis, orchestrating the initiation and execution of cellular disassembly through the cleavage of specific cellular proteins. The tetrapeptide sequence VEID in this substrate is specific for protease cleavage by caspase-6. Following caspase-6 activation, the VEID peptide is cleaved just after the aspartic acid residue (D), releasing aminoluciferin, which serves as a luminescent substrate for the luciferase reaction. The intensity of the bioluminescent signal is directly proportional to the amount of caspase-6 activity in the sample, making it a valuable tool for researchers to study and quantify apoptotic processes, screen potential drug candidates, and investigate various cellular pathways related to cell death and survival.
Spectrum
Product family
| Name | Excitation (nm) | Emission (nm) | Extinction coefficient (cm -1 M -1) |
| Z-DEVD-aminoluciferin | 362 | 499 | 18000 |
| Z-LETD-aminoluciferin | 362 | 499 | 18000 |
| Z-LEHD-aminoluciferin | 362 | 499 | 18000 |
| Z-IETD-aminoluciferin | 362 | 499 | 18000 |
| Z-VDVAD-aminoluciferin | 362 | 499 | 18000 |
| Z-ATAD-aminoluciferin | 362 | 499 | 18000 |
References
View all 10 references: Citation Explorer
MiR-320a upregulation contributes to the effectiveness of pemetrexed by inhibiting the growth and invasion of human lung cancer cell line (Calu-6).
Authors: Ghorbani Alvanegh, Akbar and Arpanaei, Ayyoob and Esmaeili Gouvarchin Ghaleh, Hadi and Mohammad Ganji, Shahla
Journal: Molecular biology reports (2024): 310
Authors: Ghorbani Alvanegh, Akbar and Arpanaei, Ayyoob and Esmaeili Gouvarchin Ghaleh, Hadi and Mohammad Ganji, Shahla
Journal: Molecular biology reports (2024): 310
Ebselen Inhibits the Growth of Lung Cancer Cells via Cell Cycle Arrest and Cell Death Accompanied by Glutathione Depletion.
Authors: Park, Woo Hyun
Journal: Molecules (Basel, Switzerland) (2023)
Authors: Park, Woo Hyun
Journal: Molecules (Basel, Switzerland) (2023)
COL11A1 Was Involved in Cell Proliferation, Apoptosis and Migration in Non-Small Cell Lung Cancer Cells.
Authors: Tu, Hongbin and Li, Jing and Lin, Lei and Wang, Lixin
Journal: Journal of investigative surgery : the official journal of the Academy of Surgical Research (2021): 664-669
Authors: Tu, Hongbin and Li, Jing and Lin, Lei and Wang, Lixin
Journal: Journal of investigative surgery : the official journal of the Academy of Surgical Research (2021): 664-669
Suberoylanilide hydroxamic acid increases anti-cancer effect of tumor necrosis factor-α through up-regulation of TNF receptor 1 in lung cancer cells.
Authors: You, Bo Ra and Han, Bo Ram and Park, Woo Hyun
Journal: Oncotarget (2017): 17726-17737
Authors: You, Bo Ra and Han, Bo Ram and Park, Woo Hyun
Journal: Oncotarget (2017): 17726-17737
PX-12 induces apoptosis in Calu-6 cells in an oxidative stress-dependent manner.
Authors: You, Bo Ra and Shin, Hye Rim and Han, Bo Ram and Park, Woo Hyun
Journal: Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine (2015): 2087-95
Authors: You, Bo Ra and Shin, Hye Rim and Han, Bo Ram and Park, Woo Hyun
Journal: Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine (2015): 2087-95
Page updated on November 23, 2024
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