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Tide Quencher™ 3WS maleimide [TQ3 maleimide]
Tide Quencher™ 3WS (TQ3WS) has been developed as an advanced quenching agent, exhibiting superior properties over traditional quenchers such as TAMRA, TF3, and Cy3. The TQ3WS quencher offers: (a) significantly increased absorption coefficients; (b) enhanced quenching efficiencies; (c) high aqueous solubility; and (d) diverse reactive derivatives suitable for conjugation with oligonucleotides and peptides. Notably, TQ3WS is the most water-soluble non-fluorescent quencher currently available for oligonucleotide and peptide applications. Our research demonstrates that TQ3WS significantly enhances the solubility of hydrophobic peptides in aqueous environments. Furthermore, TQ3WS maleimide exhibits specific and efficient reactivity with thiol groups under mildly acidic to neutral pH conditions, making it a versatile tool in bioconjugation chemistry.
Spectrum
Product family
| Name | Extinction coefficient (cm -1 M -1) | Correction Factor (260 nm) | Correction Factor (280 nm) |
| Tide Quencher™ 2WS maleimide [TQ2WS maleimide] | 48000 | 0.100 | 0.120 |
| Tide Quencher™ 4WS maleimide [TQ4WS maleimide] | 900001 | 0.149 | 0.136 |
| Tide Quencher™ 5WS maleimide [TQ5WS maleimide] | 130000 | 0.072 | 0.082 |
| Tide Quencher™ 6WS maleimide [TQ6WS maleimide] | 130000 | 0.120 | 0.102 |
| Tide Quencher™ 7WS maleimide [TQ7WS maleimide] | 140000 | 0.072 | 0.091 |
| Tide Quencher™ 1 maleimide [TQ1 maleimide] | 20000 | 0.147 | 0.194 |
| Tide Quencher™ 3 maleimide [TQ3 maleimide] | 22000 | 0.085 | 0.091 |
| Tide Quencher™ 3WS acid [TQ3WS acid] | 90000 | 0.186 | 0.205 |
| Tide Fluor™ 3WS maleimide [TF3WS maleimide] *Superior replacement for Cy3* | 150000 | - | 0.079 |
Page updated on December 17, 2024
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