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Rhod-4™ azide
Rhod-4™ azide is an excellent building block that can be readily used to prepare a calcium-sensitive bioconjugate for monitoring calcium change spatially for a specific target. It can be conjugated to alkyne-containing biomolecules via the well-known click chemistry. Rhod-4™ is a fluorescent calcium indicator dye commonly used in cell biology and neuroscience research. It belongs to the family of rhodol-based calcium. Rhod-4™ is a high-affinity calcium indicator dye that exhibits changes in fluorescence intensity upon binding to calcium ions. When Rhod-4™ binds to calcium, its fluorescence intensity increases dramatically, allowing researchers to measure and monitor changes in calcium levels. Compared to the traditional Rhod-2, Rhod-4™ is a superior replacement. It is a valuable tool in calcium imaging research, enabling the detection and quantification of intracellular calcium dynamics. It's fluorescence properties and calcium binding specificity make it suitable for studying calcium signaling in various cell types and biological systems.
Spectrum
Product family
| Name | Excitation (nm) | Emission (nm) | Quantum yield |
| Rhod-4™, AM | 523 | 551 | 0.11 |
References
View all 50 references: Citation Explorer
Mitochondria-Endoplasmic Reticulum Contact Sites Dynamics and Calcium Homeostasis Are Differentially Disrupted in PINK1-PD or PRKN-PD Neurons.
Authors: Grossmann, Dajana and Malburg, Nina and Glaß, Hannes and Weeren, Veronika and Sondermann, Verena and Pfeiffer, Julia F and Petters, Janine and Lukas, Jan and Seibler, Philip and Klein, Christine and Grünewald, Anne and Hermann, Andreas
Journal: Movement disorders : official journal of the Movement Disorder Society (2023)
Authors: Grossmann, Dajana and Malburg, Nina and Glaß, Hannes and Weeren, Veronika and Sondermann, Verena and Pfeiffer, Julia F and Petters, Janine and Lukas, Jan and Seibler, Philip and Klein, Christine and Grünewald, Anne and Hermann, Andreas
Journal: Movement disorders : official journal of the Movement Disorder Society (2023)
Cardiomyocyte Targeting Peptide to Deliver Amiodarone.
Authors: Zahid, Maliha and Weber, Beth and Yurko, Ray and Islam, Kazi and Agrawal, Vaishavi and Lopuszynski, Jack and Yagi, Hisato and Salama, Guy
Journal: bioRxiv : the preprint server for biology (2023)
Authors: Zahid, Maliha and Weber, Beth and Yurko, Ray and Islam, Kazi and Agrawal, Vaishavi and Lopuszynski, Jack and Yagi, Hisato and Salama, Guy
Journal: bioRxiv : the preprint server for biology (2023)
Palmitic acid methyl ester induces cardiac hypertrophy through activating the GPR receptor-mediated changes of intracellular calcium concentrations and mitochondrial functions.
Authors: Lien, Chih-Feng and Chiu, Hung-Wen and Lee, Wen-Sen and Lin, Jian-Hong and Wang, Yi-Shun and Ting, Pei-Ching and Luo, Yu-Po and Chang, Jui-Chih and Yang, Kun-Ta
Journal: Journal of cellular physiology (2023): 242-256
Authors: Lien, Chih-Feng and Chiu, Hung-Wen and Lee, Wen-Sen and Lin, Jian-Hong and Wang, Yi-Shun and Ting, Pei-Ching and Luo, Yu-Po and Chang, Jui-Chih and Yang, Kun-Ta
Journal: Journal of cellular physiology (2023): 242-256
CDN1163, a SERCA activator, causes intracellular Ca2+ leak, mitochondrial hyperpolarization and cell cycle arrest in mouse neuronal N2A cells.
Authors: Huang, Yi-Ping and Huang, Wen-Wei and Tsai, Kun-Feng and Shiao, Lian-Ru and Yang, Zih-He and Tseng, Shao-Yun and Lin, Yu-Hsien and Chen, Cing-Yu and Chan, Paul and Leung, Yuk-Man
Journal: Neurotoxicology (2023): 9-15
Authors: Huang, Yi-Ping and Huang, Wen-Wei and Tsai, Kun-Feng and Shiao, Lian-Ru and Yang, Zih-He and Tseng, Shao-Yun and Lin, Yu-Hsien and Chen, Cing-Yu and Chan, Paul and Leung, Yuk-Man
Journal: Neurotoxicology (2023): 9-15
Piezo1 channel activation stimulates ATP production through enhancing mitochondrial respiration and glycolysis in vascular endothelial cells.
Authors: Jiang, Man and Zhang, Yi-Xin and Bu, Wen-Jie and Li, Ping and Chen, Jia-Hui and Cao, Ming and Dong, Yan-Chao and Sun, Zhi-Jie and Dong, De-Li
Journal: British journal of pharmacology (2023): 1862-1877
Authors: Jiang, Man and Zhang, Yi-Xin and Bu, Wen-Jie and Li, Ping and Chen, Jia-Hui and Cao, Ming and Dong, Yan-Chao and Sun, Zhi-Jie and Dong, De-Li
Journal: British journal of pharmacology (2023): 1862-1877
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