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Psoralen TMP Azide
Psoralen TMP Azide is an excellent building block for developing site-specific nucleic acid probes via the well-known click chemistry, i.e., Copper-Catalyzed Alkyne–Azide Cycloaddition (CuAAC). It can be readily conjugated to azido-containing biomolecules (such as alkynyl-modified antibodies, peptide alkynes and alkynyl-modified oligos). Psoralens and their derivatives (such as 8-TMP and 4,5’,8-TMP) are well known to have unique crosslinking features to DNA. Psoralen TMP Azide is an alkynyl-reactive TMP derivative. It is an excellent building block for preparing TMP-labeled oligos from an alkynyl-modified oligo. The TMP-conjugated oligonucleotides can be used for sequence-specific crosslinking with a target DNA, thus enabling the application of psoralen-conjugated molecules in gene transcription inhibition, gene knockout, and other genomic applications.
References
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Allosteric regulation of U1 snRNP by splicing regulatory proteins controls spliceosomal assembly.
Authors: Shenasa, Hossein and Movassat, Maliheh and Forouzmand, Elmira and Hertel, Klemens J
Journal: RNA (New York, N.Y.) (2020): 1389-1399
Authors: Shenasa, Hossein and Movassat, Maliheh and Forouzmand, Elmira and Hertel, Klemens J
Journal: RNA (New York, N.Y.) (2020): 1389-1399
In yeast cells arrested at the early S-phase by hydroxyurea, rRNA gene promoters and chromatin are poised for transcription while rRNA synthesis is compromised.
Authors: Charton, Romain and Muguet, Alexia and Griesenbeck, Joachim and Smerdon, Michael J and Conconi, Antonio
Journal: Mutation research (2019): 20-29
Authors: Charton, Romain and Muguet, Alexia and Griesenbeck, Joachim and Smerdon, Michael J and Conconi, Antonio
Journal: Mutation research (2019): 20-29
Analyses of rRNA gene chromatin in cell cycle arrested Saccharomyces cerevisiae cells.
Authors: Paillé, Audrey and Charton, Romain and Muguet, Alexia and Griesenbeck, Joachim and Smerdon, Michael J and Conconi, Antonio
Journal: Data in brief (2019): 104083
Authors: Paillé, Audrey and Charton, Romain and Muguet, Alexia and Griesenbeck, Joachim and Smerdon, Michael J and Conconi, Antonio
Journal: Data in brief (2019): 104083
Dynamic Architecture of Eukaryotic DNA Replication Forks In Vivo, Visualized by Electron Microscopy.
Authors: Zellweger, Ralph and Lopes, Massimo
Journal: Methods in molecular biology (Clifton, N.J.) (2018): 261-294
Authors: Zellweger, Ralph and Lopes, Massimo
Journal: Methods in molecular biology (Clifton, N.J.) (2018): 261-294
Mapping RNA-RNA Interactions Globally Using Biotinylated Psoralen.
Authors: Aw, Jong Ghut Ashley and Shen, Yang and Nagarajan, Niranjan and Wan, Yue
Journal: Journal of visualized experiments : JoVE (2017)
Authors: Aw, Jong Ghut Ashley and Shen, Yang and Nagarajan, Niranjan and Wan, Yue
Journal: Journal of visualized experiments : JoVE (2017)
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