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Psoralen TMP Alkyne
Psoralen TMP Alkyne is an excellent building block for developing site-specific nucleic acid probes via the well-known click chemistry, i.e., Copper-Catalyzed Azide–Alkyne Cycloaddition (CuAAC). It can be readily conjugated to azido-containing biomolecules (such as azido-modified antibodies, peptide azides and azido-modified oligos). Psoralens and their derivatives (such as 8-TMP and 4,5’,8-TMP) are well known to have unique crosslinking features to DNA. Psoralen TMP Alkyne is an azide-reactive TMP derivative. It is an excellent building block for preparing TMP-labeled oligos from an azido-modified oligo. The TMP-conjugated oligonucleotides can be used for sequence-specific crosslinking with a target DNA, thus enabling the application of psoralen-conjugated molecules in gene transcription inhibition, gene knockout, and other genomic applications.
References
View all 7 references: Citation Explorer
Computer modeling of three-dimensional structure of DNA-packaging RNA (pRNA) monomer, dimer, and hexamer of Phi29 DNA packaging motor.
Authors: Hoeprich, Stephen and Guo, Peixuan
Journal: The Journal of biological chemistry (2002): 20794-803
Authors: Hoeprich, Stephen and Guo, Peixuan
Journal: The Journal of biological chemistry (2002): 20794-803
Photoaffinity behavior of a conjugate of oligonucleoside methylphosphonate, rhodamine, and psoralen in the presence of complementary oligonucleotides.
Authors: Thaden, J and Miller, P S
Journal: Bioconjugate chemistry (1993): 386-94
Authors: Thaden, J and Miller, P S
Journal: Bioconjugate chemistry (1993): 386-94
Laser-induced protein-DNA cross-links via psoralen furanside monoadducts.
Authors: Sastry, S S and Spielmann, H P and Hoang, Q S and Phillips, A M and Sancar, A and Hearst, J E
Journal: Biochemistry (1993): 5526-38
Authors: Sastry, S S and Spielmann, H P and Hoang, Q S and Phillips, A M and Sancar, A and Hearst, J E
Journal: Biochemistry (1993): 5526-38
Lethal and mutagenic effects photoinduced in haploid yeast (Saccharomyces cerevisiae) by two new monofunctional pyridopsoralens compared to 3-carbethoxypsoralen and 8-methoxypsoralen.
Authors: Averbeck, D and Averbeck, S and Bisagni, E and Moron, L
Journal: Mutation research (1985): 47-57
Authors: Averbeck, D and Averbeck, S and Bisagni, E and Moron, L
Journal: Mutation research (1985): 47-57
Organization of herpes simplex virus type 1 deoxyribonucleic acid during replication probed in living cells with 4,5',8-trimethylpsoralen.
Authors: Sinden, R R and Pettijohn, D E and Francke, B
Journal: Biochemistry (1982): 4484-90
Authors: Sinden, R R and Pettijohn, D E and Francke, B
Journal: Biochemistry (1982): 4484-90
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