OxiVision™ Lipid Peroxide Sensor

• Selective Lipid Peroxide Detection: High specificity for lipid peroxides.
• Enhanced Solubility: Tetraethyleneglycol moiety increases solubility in aqueous buffers.
• Lipid-Specific Fluorescence: Minimal fluorescence in aqueous, strong fluorescence in lipophilic environments (e.g., membranes).
• Versatile Applications: Suitable for fluorescence microscopy and flow cytometry in live cell assays.
• Ferroptosis Research Utility: Ideal for lipid peroxidation studies, especially in ferroptosis.

The OxiVision™ Lipid Peroxide Sensor is a perylene-based derivative functionalized with oligooxyethylene, designed for the selective detection of lipid peroxides. Upon oxidation by lipid peroxides, this sensor exhibits robust fluorescence in organic solvents, such as ethanol. Distinct from conventional ROS probes, the OxiVision™ Lipid Peroxide Sensor demonstrates a unique specificity for lipid peroxides. The oxidized sensor is characterized by excitation and emission maxima at 524 nm and 535 nm, respectively, enabling reduced photodamage and minimized autofluorescence in biological samples. The sensor's structure is further optimized by the addition of a tetraethyleneglycol moiety on the diisoquinoline ring, significantly enhancing its solubility and dispersibility in aqueous buffers. In its oxidized state, the sensor shows minimal fluorescence in aqueous environments but becomes highly fluorescent in lipophilic conditions, such as cellular membranes. This property is particularly advantageous for lipid peroxide imaging via fluorescence microscopy and for quantifying lipid peroxides in live cell assays using flow cytometry. OxiVision™ Lipid Peroxide Sensor is a powerful tool for studying lipid peroxidation processes, with particular relevance to ferroptosis research.