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OxiVision™ Green hydrogen peroxide sensor
Despite the importance of H2O2 to human health and disease, the molecular mechanisms of its production, accumulation, trafficking, and function are insufficiently understood due to the lack of sensitive and specific H2O2 sensors that can be used in live cells. The limitations of currently available H2O2-responsive probes include interfering background fluorescence from other ROS, the need for an external activating enzyme, lack of water solubility or compatibility, and/or excitation profiles in the ultraviolet region. OxiVision Green™ hydrogen peroxide sensor is non-fluorescent and displays no absorption in the visible region. The addition of H2O2 triggers a prompt fluorescence increase with concomitant growth of a visible wavelength absorption band. This probe has a large dynamic range owing to its binary absorption/emission response. The fluorescence response of OxiVision Green™ hydrogen peroxide sensor is H2O2-selective. OxiVision Green™ hydrogen peroxide sensor exhibits a >100-fold selectivity for H2O2 over similar ROS such as O2-, NO, or -OCl.
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Citations
View all 16 citations: Citation Explorer
SOD1 Is an Integral Yet Insufficient Oxidizer of Hydrogen Sulfide in Trisomy 21 B Lymphocytes and Can Be Augmented by a Pleiotropic Carbon Nanozyme
Authors: Mouli, Karthik and Liopo, Anton V and Suva, Larry J and Olson, Kenneth R and McHugh, Emily A and Tour, James M and Derry, Paul J and Kent, Thomas A
Journal: Antioxidants (2024): 1361
Authors: Mouli, Karthik and Liopo, Anton V and Suva, Larry J and Olson, Kenneth R and McHugh, Emily A and Tour, James M and Derry, Paul J and Kent, Thomas A
Journal: Antioxidants (2024): 1361
Exosome-Coated Prussian Blue Nanoparticles for Specific Targeting and Treatment of Glioblastoma
Authors: Hill, Meghan L and Chung, Seock-Jin and Woo, Hyun-Joo and Park, Cho Rong and Hadrick, Kay and Nafiujjaman, Md and Kumar, Panangattukara Prabhakaran Praveen and Mwangi, Leila and Parikh, Rachna and Kim, Taeho
Journal: ACS Applied Materials \& Interfaces (2024)
Authors: Hill, Meghan L and Chung, Seock-Jin and Woo, Hyun-Joo and Park, Cho Rong and Hadrick, Kay and Nafiujjaman, Md and Kumar, Panangattukara Prabhakaran Praveen and Mwangi, Leila and Parikh, Rachna and Kim, Taeho
Journal: ACS Applied Materials \& Interfaces (2024)
Selenite selectively kills lung fibroblasts to treat bleomycin-induced pulmonary fibrosis
Authors: Lin, Jiun-Han and Liu, Chen-Chi and Liu, Chao-Yu and Hsu, Tien-Wei and Yeh, Yi-Chen and How, Chorng-Kung and Hsu, Han-Shui and Hung, Shih-Chieh
Journal: Redox Biology (2024): 103148
Authors: Lin, Jiun-Han and Liu, Chen-Chi and Liu, Chao-Yu and Hsu, Tien-Wei and Yeh, Yi-Chen and How, Chorng-Kung and Hsu, Han-Shui and Hung, Shih-Chieh
Journal: Redox Biology (2024): 103148
Rational design of ICD-inducing nanoparticles for cancer immunotherapy
Authors: Zhang, Zhanzhan and Pan, Zheng and Li, Qiushi and Huang, Qingqing and Shi, Linqi and Liu, Yang
Journal: Science Advances (2024): eadk0716
Authors: Zhang, Zhanzhan and Pan, Zheng and Li, Qiushi and Huang, Qingqing and Shi, Linqi and Liu, Yang
Journal: Science Advances (2024): eadk0716
Superoxide Dismutase-like Activity of Zeolitic Imidazolate Framework Nanoparticles Comprising Biomimetic Imidazolato-bridged CuZn Units
Authors: Nakahara, Hiroki and Nomura, Akiko and Tokuda, Shun and Okamura, Mami and Fujisawa, Kiyoshi and Koitaya, Takanori and Yoshida, Yasuhiro and Furukawa, Shuhei and Hitomi, Yutaka
Journal: Chemistry--A European Journal (2023): e202300881
Authors: Nakahara, Hiroki and Nomura, Akiko and Tokuda, Shun and Okamura, Mami and Fujisawa, Kiyoshi and Koitaya, Takanori and Yoshida, Yasuhiro and Furukawa, Shuhei and Hitomi, Yutaka
Journal: Chemistry--A European Journal (2023): e202300881
References
View all 54 references: Citation Explorer
Genetically encoded fluorescent indicator for intracellular hydrogen peroxide
Authors: Belousov VV, Fradkov AF, Lukyanov KA, Staroverov DB, Shakhbazov KS, Terskikh AV, Lukyanov S.
Journal: Nat Methods (2006): 281
Authors: Belousov VV, Fradkov AF, Lukyanov KA, Staroverov DB, Shakhbazov KS, Terskikh AV, Lukyanov S.
Journal: Nat Methods (2006): 281
Specific aquaporins facilitate the diffusion of hydrogen peroxide across membranes
Authors: Bienert GP, Moller AL, Kristiansen KA, Schulz A, Moller IM, Schjoerring JK, Jahn TP.
Journal: J Biol Chem. (2006)
Authors: Bienert GP, Moller AL, Kristiansen KA, Schulz A, Moller IM, Schjoerring JK, Jahn TP.
Journal: J Biol Chem. (2006)
Enzymatic oxidation of dipyridamole in homogeneous and micellar solutions in the horseradish peroxidase-hydrogen peroxide system
Authors: Almeida LE, Imasato H, Tabak M.
Journal: Biochim Biophys Acta (2006): 216
Authors: Almeida LE, Imasato H, Tabak M.
Journal: Biochim Biophys Acta (2006): 216
Fluorescent quenching method for determination of trace hydrogen peroxide in rain water
Authors: Chen H, Yu H, Zhou Y, Wang L.
Journal: Spectrochim Acta A Mol Biomol Spectrosc. (2006)
Authors: Chen H, Yu H, Zhou Y, Wang L.
Journal: Spectrochim Acta A Mol Biomol Spectrosc. (2006)
Nonenzymatic direct assay of hydrogen peroxide at neutral pH using the Eu3Tc fluorescent probe
Authors: Durkop A, Wolfbeis OS.
Journal: J Fluoresc (2005): 755
Authors: Durkop A, Wolfbeis OS.
Journal: J Fluoresc (2005): 755
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