MitoLite™ NIR FX690

Mitochondria are membrane-enclosed organelles found in most eukaryotic cells. Mitochondria generate most of the cellular supply of ATP. In addition to supplying cellular energy, mitochondria are involved in a range of other processes, such as signaling, cellular differentiation, cell death, as well as the control of the cell cycle and cell growth. Mitochondria have been implicated in several human diseases, including mitochondrial disorders and cardiac dysfunction, and may play a role in the aging process. Mitolite™ NIR FX690 is designed to label mitochondria in live cells with near infrared fluorescence. It selectively accumulates in mitochondria probably via the mitochondrial membrane potential gradient. It is an ideal choice for imaging live cells and tissues where low background, and high signal-to-noise ratio is critical. This fluorescent mitochondrial indicator is retained in mitochondria for a long time since it carries a cell-retaining group. This key feature significantly increases the staining efficiency. It is useful for a variety of studies, including cell adhesion, chemotaxis, multidrug resistance, cell viability, apoptosis and cytotoxicity.

Page updated on November 21, 2024