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Concanavalin A, XFD594 Labeled *XFD594 Same Structure to Alexa Fluor™ 594*
Ordering information
| Price | |
| Catalog Number | |
| Unit Size | |
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Additional ordering information
| Telephone | 1-800-990-8053 |
| Fax | 1-800-609-2943 |
| sales@aatbio.com | |
| International | See distributors |
| Bulk request | Inquire |
| Custom size | Inquire |
| Shipping | Standard overnight for United States, inquire for international |
Physical properties
| Molecular weight | N/A |
| Solvent | Water |
Spectral properties
| Absorbance (nm) | 592 |
| Correction Factor (260 nm) | 0.43 |
| Correction Factor (280 nm) | 0.56 |
| Extinction coefficient (cm -1 M -1) | 92000 |
| Excitation (nm) | 590 |
| Emission (nm) | 618 |
| Quantum yield | 0.661 |
Storage, safety and handling
| H-phrase | H303, H313, H333 |
| Hazard symbol | XN |
| Intended use | Research Use Only (RUO) |
| R-phrase | R20, R21, R22 |
| Storage | Freeze (< -15 °C); Minimize light exposure |
| UNSPSC | 12171501 |
| Overview |  SDSProtocol |
See also: Antibody and Protein Labeling
Molecular weight N/A | Absorbance (nm) 592 | Correction Factor (260 nm) 0.43 | Correction Factor (280 nm) 0.56 | Extinction coefficient (cm -1 M -1) 92000 | Excitation (nm) 590 | Emission (nm) 618 | Quantum yield 0.661 |
XFD594 is manufactured by AAT Bioquest, and it has the same chemical structure of Alexa Fluor® 594 (Alexa Fluor® is the trademark of ThermoFisher). Concanavalin A (ConA) is a lectin that binds specifically to certain structures found in various sugars, glycoproteins and glycolipids. ConA is widely used in biology and biochemistry to characterize glycoproteins and other sugar-containing entities on the surface of various cells. It is also used to purify glycosylated macromolecules in lectin affinity chromatography, as well as to study immune regulation by various immune cells. ConA binds specifically α-D-mannosyl and α-D-glucosyl residues (two hexoses differing only in the alcohol on carbon 2) in terminal position of ramified structures from B-Glycans. Concanavalin A (Con A) is one of the most widely used lectins in cell biology. XFD594-labeled Concanavalin A (equivalent to Alexa Fluor® 594 conjugate of Con A, Alexa Fluor® is the trademark of ThermoFisher) exhibits the bright, red fluorescence. XFD594 Con A selectively binds to a-mannopyranosyl and a-glucopyranosyl residues.
Platform
Fluorescence microscope
| Excitation | Cy3/TRITC filter set |
| Emission | Cy3/TRITC filter set |
| Recommended plate | Black wall/clear bottom |
Spectrum
Open in Advanced Spectrum Viewer
Spectral properties
| Absorbance (nm) | 592 |
| Correction Factor (260 nm) | 0.43 |
| Correction Factor (280 nm) | 0.56 |
| Extinction coefficient (cm -1 M -1) | 92000 |
| Excitation (nm) | 590 |
| Emission (nm) | 618 |
| Quantum yield | 0.661 |
Product Family
| Name | Excitation (nm) | Emission (nm) | Extinction coefficient (cm -1 M -1) | Quantum yield | Correction Factor (260 nm) | Correction Factor (280 nm) |
| Concanavalin A, XFD488 Labeled *XFD488 Same Structure to Alexa Fluor™ 488* | 499 | 520 | 73000 | 0.921 | 0.3 | 0.11 |
References
View all 50 references: Citation Explorer
Short-term high-fat diet intake leads to exacerbation of concanavalin A-induced liver injury through the induction of procoagulation state.
Authors: Nanizawa, Eri and Tamaki, Yuki and Sono, Reika and Miyashita, Rintaro and Hayashi, Yumi and Kanbe, Ayumu and Ito, Hiroyasu and Ishikawa, Tetsuya
Journal: Biochemistry and biophysics reports (2020): 100736
Authors: Nanizawa, Eri and Tamaki, Yuki and Sono, Reika and Miyashita, Rintaro and Hayashi, Yumi and Kanbe, Ayumu and Ito, Hiroyasu and Ishikawa, Tetsuya
Journal: Biochemistry and biophysics reports (2020): 100736
Montelukast ameliorates Concanavalin A-induced autoimmune hepatitis in mice via inhibiting TNF-α/JNK signaling pathway.
Authors: El-Kashef, Dalia H and Abdelrahman, Rehab S
Journal: Toxicology and applied pharmacology (2020): 114931
Authors: El-Kashef, Dalia H and Abdelrahman, Rehab S
Journal: Toxicology and applied pharmacology (2020): 114931
Acupuncture stimulation attenuates TNF-α production via vagal modulation in the concanavalin A model of hepatitis.
Authors: Lim, Hee-Don and Kim, Ki-Joong and Jo, Byung Gon and Park, Ji-Yeun and Namgung, Uk
Journal: Acupuncture in medicine : journal of the British Medical Acupuncture Society (2020): 964528420907338
Authors: Lim, Hee-Don and Kim, Ki-Joong and Jo, Byung Gon and Park, Ji-Yeun and Namgung, Uk
Journal: Acupuncture in medicine : journal of the British Medical Acupuncture Society (2020): 964528420907338
Deficiency of O-linked-glycosylation regulates activation of T cells and aggravates Concanavalin A-induced liver injury.
Authors: Hao, Xiaohua and Gao, Meixin and He, Lingling and Ye, Xiaohui and Yang, Junru and Zhang, Fuyang and Liu, Ran and Wei, Hongshan
Journal: Toxicology (2020): 152411
Authors: Hao, Xiaohua and Gao, Meixin and He, Lingling and Ye, Xiaohui and Yang, Junru and Zhang, Fuyang and Liu, Ran and Wei, Hongshan
Journal: Toxicology (2020): 152411
Nicotine attenuates concanavalin A-induced liver injury in mice by regulating the α7-nicotinic acetylcholine receptor in Kupffer cells.
Authors: Zhao, Jing and Park, Surim and Kim, Jong-Won and Qi, Jing and Zhou, Zixiong and Lim, Chae Woong and Kim, Bumseok
Journal: International immunopharmacology (2020): 106071
Authors: Zhao, Jing and Park, Surim and Kim, Jong-Won and Qi, Jing and Zhou, Zixiong and Lim, Chae Woong and Kim, Bumseok
Journal: International immunopharmacology (2020): 106071
The high-resolution proteomic analysis of protein composition of rat spleen lymphocytes stimulated by Concanavalin A; a comparison with morphine-treated cells.
Authors: Ujcikova, Hana and Cechova, Kristina and Roubalova, Lenka and Brejchova, Jana and Kaufman, Jonas and Holan, Vladimir and Svoboda, Petr
Journal: Journal of neuroimmunology (2020): 577191
Authors: Ujcikova, Hana and Cechova, Kristina and Roubalova, Lenka and Brejchova, Jana and Kaufman, Jonas and Holan, Vladimir and Svoboda, Petr
Journal: Journal of neuroimmunology (2020): 577191
Surface-imprinted silica particles for Concanavalin A purification from Canavalia ensiformis.
Authors: Razym, Galiya and Bakhshpour, Monireh and Yavuz, Handan and Kip, Çiğdem and Tuncel, Ali and Denizli, Adil
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (2020): 121852
Authors: Razym, Galiya and Bakhshpour, Monireh and Yavuz, Handan and Kip, Çiğdem and Tuncel, Ali and Denizli, Adil
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (2020): 121852
Pregabalin inhibits in vivo and in vitro cytokine secretion and attenuates spleen inflammation in Lipopolysaccharide/Concanavalin A -induced murine models of inflammation.
Authors: Abu-Rish, Eman Y and Mansour, Ahmad T and Mansour, Hebah T and Dahabiyeh, Lina A and Aleidi, Shereen M and Bustanji, Yasser
Journal: Scientific reports (2020): 4007
Authors: Abu-Rish, Eman Y and Mansour, Ahmad T and Mansour, Hebah T and Dahabiyeh, Lina A and Aleidi, Shereen M and Bustanji, Yasser
Journal: Scientific reports (2020): 4007
The Role of Serotonin in Concanavalin A-Induced Liver Injury in Mice.
Authors: Pang, Qing and Jin, Hao and Ke, Xiquan and Man, Zhongran and Wang, Yong and Tan, Yi and Lu, Zheng and Liu, Huichun
Journal: Oxidative medicine and cellular longevity (2020): 7504521
Authors: Pang, Qing and Jin, Hao and Ke, Xiquan and Man, Zhongran and Wang, Yong and Tan, Yi and Lu, Zheng and Liu, Huichun
Journal: Oxidative medicine and cellular longevity (2020): 7504521
A Rabbit Model of Aqueous-Deficient Dry Eye Disease Induced by Concanavalin A Injection into the Lacrimal Glands: Application to Drug Efficacy Studies.
Authors: Honkanen, Robert A and Huang, Liqun and Rigas, Basil
Journal: Journal of visualized experiments : JoVE (2020)
Authors: Honkanen, Robert A and Huang, Liqun and Rigas, Basil
Journal: Journal of visualized experiments : JoVE (2020)
Application notes
A Meta-Analysis of Common Calcium Indicators
A New Protein Crosslinking Method for Labeling and Modifying Antibodies
A Novel Fluorescent Probe for Imaging and Detecting Hydroxyl Radical in Living Cells
A Novel NO Wash Probeniceid-Free Calcium Assay for Functional Analysis of GPCR and Calcium Channel Targets
Abbreviation of Common Chemical Compounds Related to Peptides
A New Protein Crosslinking Method for Labeling and Modifying Antibodies
A Novel Fluorescent Probe for Imaging and Detecting Hydroxyl Radical in Living Cells
A Novel NO Wash Probeniceid-Free Calcium Assay for Functional Analysis of GPCR and Calcium Channel Targets
Abbreviation of Common Chemical Compounds Related to Peptides
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