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AAT Bioquest

Where does Krebs cycle or TCA cycle occur?

Posted March 30, 2023


Answer

Krebs cycle or TCA cycle occurs in the mitochondrial matrix, a dense solution in the innermost part of the mitochondria. Pyruvate, which is formed in the cell cytosol, is imported into the mitochondria, where it is converted to acetyl CoA. The acetyl CoA is transferred to the matrix of the mitochondria, which contains all the enzymes and coenzymes required for the biochemical reactions of the Krebs cycle.

Additional resources

Krebs cycle: activators, inhibitors and their roles in the modulation of carcinogenesis

Mitochondria

Cellular Processes

Amplite® Colorimetric Pyruvate Assay Kit