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AAT Bioquest

What do osteoclasts do?

Posted June 17, 2024


Answer

Osteoclasts serve three important functions during bone resorption: 

  • Generate digestive enzymes and acids that break down old and damaged bone, making space for osteoblasts to lay down new, healthier bone tissue 
  • Release calcium into the bloodstream on degradation of hydroxyapatite 
  • Release amino acids into the bloodstream on degradation of collagen proteins
Additional resources

Advances in the regulation of osteoclasts and osteoclast functions

Immunohistochemistry (IHC)

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