logo
AAT Bioquest

What determines the solubility of a given solute in a given solvent?

Posted August 26, 2024


Answer

The factors determining the solubility of a given solute in a given solvent include pressure, temperature, and polarity. The solubility of most solid solutes in liquids generally increases as the temperature rises. This is because higher temperatures cause the solvent molecules to move faster and interact more effectively with the solute, helping it dissolve more readily. The solubility of gasses in liquids typically decreases with increasing temperature; hot liquids provide more energy, which causes gas molecules to escape from the solution. For liquids, temperature does not show a predictable trend in how it impacts their solubility in other liquids. A substance will dissolve more effectively in a solvent with a similar chemical nature. For example, polar solutes (like sugar) dissolve well in polar solvents (like water) because they interact strongly with each other.  Pressure has little impact on the solubility of solids and liquids. Pressure significantly affects the solubility of gasses; higher pressure increases the amount of gas that can dissolve in a liquid. 

Additional resources

Solubility and Factors Affecting Solubility

Solubility Reference Table

SMCC Plus™ *Enhanced water solubility, crosslinking efficiency and stability*

Serial Dilution Calculator and Planner