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AAT Bioquest

What are the main results of reversible cell injury?

Posted January 26, 2023


Answer

One main result of reversible cell injury is the depletion of ATP resources in the cell due to the decreased rate of oxidative phosphorylation because of the oxidative stress. Another result is that organelles will have been slightly altered but will not affect primary cellular functions. A third result is the hydropic cellular swelling as a result of the osmotic imbalances from chemicals and ions or from external injury caused on the plasma membrane. It is important to note that these changes are reversible once the cell returns to normal homeostatic conditions. Reversible cell injury leads to adaptation of the cells or tissue. Adaptive changes to cells include atrophy, hypertrophy, hyperplasia, or metaplasia. These cells may also have a build-up of substances like fat, lipids, protein, cholesterol, glycogen, or pigment. Cellular blebbing, mitochondrial changes, and dilation of the ER may also occur during reversible cell injury. 

Additional resources

Mechanisms and Morphology of Cellular Injury, Adaptation, and Death

Cell Structures and Organelles

Cell Meter™ Intracellular NADH/NADPH Flow Cytometric Analysis Kit *Red Fluorescence*

PhosphoWorks™ Colorimetric ATP Assay Kit