What are the examples of feedback inhibition?

ATP production

ATP production, which is the conversion of glucose into ATP through enzymatic reactions, is a well-known example of feedback inhibition. Glucose serves as a steady energy source, obtainable from food and transportable throughout the body. ATP, however, is inherently unstable, requiring regulation to prevent energy loss from its spontaneous breakdown. The first enzyme in the glucose breakdown pathway is allosterically regulated by ATP binding to the enzyme, which prevents it from breaking down any more glucose. This ensures controlled ATP production based on cellular energy demands – producing ample amounts of ATP when it is needed and used up quickly but reducing production when only little ATP is needed. 

Cholesterol synthesis

Cholesterol synthesis is another chemical reaction that is regulated through feedback inhibition. Cholesterol plays a key role in facilitation communication between cells and in maintaining membrane integrity. However, excess cholesterol levels can have a detrimental effect. In instances of high dietary cholesterol intake, it is crucial for the body to be able to curb cholesterol synthesis. Feedback inhibition mechanisms come into play by reducing cholesterol production when blood levels are elevated, ensuring a balanced cholesterol level within the body.