What are the disadvantages of using multiple-sample sonicators for chromatin fragmentation?

A drawback of multi-sample sonicators is their potential costliness, particularly for the expense of plates required for certain high-throughput models. It can amount to hundreds of dollars. Another limitation is that most existing sonication systems either cannot accommodate high-throughput sample processing or necessitate costly proprietary plates or tubes. This lack of versatility may require the purchase of additional equipment or accessories to accommodate different experimental setups. Additionally, before using most multi-sample sonicators, it's essential to degas the water. This step is crucial because any air bubbles or contamination in the water can disrupt the acoustic wave and cause it to scatter. The duration of degassing varies depending on the device and may take several hours in some instances.