What are the differences between myeloblast and lymphoblast?

Question

Accepted Answer

Basis of differentiation

Myeloblast

Lymphoblast

Definition

immature blood cells produced in bone marrow serves as the precursor of myelocytes

immature blood cells produced in bone marrow that serves as the precursor of lymphocytes

Diameter

20 µm

15 µm

Presence of granules

Contains granules in the cytoplasm

Cytoplasmic granules are absent

Shape of the nucleus

Nucleus may be S, C or V-shaped

Nucleus is rounded

Nucleoli

The nucleus has a prominent nucleoli

The nucleus has less distinct nucleoli

Chromatin condensation

Chromatin is less condensed

Chromatin is highly condensed

Differentiate into

Basophils
Neutrophils
Eosinophils

T lymphocytes
B lymphocytes

Pathology

Dysfunction can cause acute myeloblastic  leukemia  (AML)

Dysfunction can cause acute lymphoblastic  leukemia (ALL)

Basis of differentiation	Myeloblast	Lymphoblast
Definition	immature blood cells produced in bone marrow serves as the precursor of myelocytes	immature blood cells produced in bone marrow that serves as the precursor of lymphocytes
Diameter	20 µm	15 µm
Presence of granules	Contains granules in the cytoplasm	Cytoplasmic granules are absent
Shape of the nucleus	Nucleus may be S, C or V-shaped	Nucleus is rounded
Nucleoli	The nucleus has a prominent nucleoli	The nucleus has less distinct nucleoli
Chromatin condensation	Chromatin is less condensed	Chromatin is highly condensed
Differentiate into	Basophils Neutrophils Eosinophils	T lymphocytes B lymphocytes
Pathology	Dysfunction can cause acute myeloblastic leukemia (AML)	Dysfunction can cause acute lymphoblastic leukemia (ALL)