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What are the common variables that increase molecule passage?
Posted April 19, 2024

Answer

Common variables that increase molecule passage: 

  • Differences between linear and globular molecules 
  • Low sample concentration below 1 mg/mL 
  • Buffer composition that promotes the disintegration of molecules, influenced by pH and ionic conditions that change the molecule’s conformation or aggregation properties
  • Elevated transmembrane pressure induced by gravitational force in centrifugal concentrators - particularly impactful for linear molecules such as DNA fragments. Lowering the g-force can enhance the membrane’s molecule retention.