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AAT Bioquest

What are the chemical reactions of amines?

Posted May 23, 2024


Answer

There are several different chemical reactions involved with amines. 

  1. When amines are exposed to acids, they donate electrons, leading to the formation of ammonium salts. 
  2. When sulfonyl chlorides interact with amines, they yield sulfonamides. 
  3. When acid halides encounter amines, they undergo a reaction resulting in the formation of substituted amides. 
  4. Aldehydes and ketones, when combined with primary amines, generate a reaction product known as carbinolamine. This subsequently dehydrates to yield aldimines and ketimines, which are known as Schiff bases. 
  5. When secondary amines pair with aldehydes or ketones, they give rise to enamines. 
  6. Ammonia, primary amines, and secondary amines readily undergo reactions with acid chlorides or acid anhydrides to produce primary, secondary, and tertiary amides, respectively.
Additional resources

Chemical Reactions of Amines - Acylation and Basicity

Amine Reactive Dyes and Probes for Conjugation

iFluor® 488 succinimidyl ester