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AAT Bioquest

What are the applications of restriction fragment length polymorphism (RELP)?

Posted June 25, 2024


Answer

One application of RFLP is diagnosing genetic diseases like Cystic Fibrosis by identifying specific DNA variations associated with the disease in an individual's genome. Another application is that RFLP is crucial in genetic mapping studies to determine the distance between genetic markers (loci) on chromosomes. By analyzing the inheritance patterns of RFLP markers in families, researchers can create genetic maps that provide information into the inheritance of genes. Additionally, RFLP analysis is used to identify carriers of disease-causing mutations within families. RFLP is also used in forensic science to analyze DNA samples from crime scenes or paternity tests to determine the source of the sample.

Additional resources

Restriction Fragment Length Polymorphism (RFLP)

DNA Fragmentation

Gelite™ Green Nucleic Acid Gel Staining Kit