What are the advantages of using wheat germ agglutinin (WGA) as a marker?

One advantage of using wheat germ agglutinin (WGA) as a marker is that WGA has high affinity for specific carbohydrate residues on glycoproteins and glycolipids, allowing for precise labeling of cell surfaces. Another pro is the labeling process with WGA is relatively straightforward and does not require complex procedures. WGA can also potentially be used for targeting drug carriers to the blood-brain barrier (BBB) due to its strong binding affinity for cerebral capillary endothelial cells. WGA has also demonstrated cytotoxic effects against osteosarcoma, pancreatic cancer, and hepatoma cells.