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AAT Bioquest

Do neurons have the Major Histocompatibility Complex (MHC)?

Posted August 26, 2024


Answer

No, neurons do not have the Major Histocompatibility Complex (MHC). 

Major Histocompatibility Complex is a cell cluster that is found on the surface of nucleated cells. Neurons, which are cells of the nervous system, are anucleated, and as such they do not have the MHC.  

Additional resources

Chapter 10 Major histocompatibility complex: Antigen processing and presentation

Immunohistochemistry (IHC)

iFluor® 488 PSA™ Imaging Kit with Goat Anti-Mouse IgG