What is the role of p53 in DNA damage repair system?

Tumor protein p53 plays an important role in cell regulation and conserving the genomic stability, which is achieved by means of several mechanisms:

• Activating DNA repair proteins when DNA has sustained damage.
• Arresting growth by holding the cell cycle at the G1/S regulation point on DNA damage recognition.
• Initiating apoptosis if DNA damage is irreparable.
• Serving as a critical component for the senescence response to short telomeres.