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Z-DEVD-FMK

Z-DEVD-FMK is a specific, irreversible Caspase-3 inhibitor, and also shows potent inhibition on caspase-6, caspase-7, caspase-8, and caspase-10.

References

View all 50 references: Citation Explorer
Rescue of Escherichia coli cells from UV-induced death and filamentation by caspase-3 inhibitor.
Authors: Wadhawan, Surbhi and Gautam, Satyendra
Journal: International microbiology : the official journal of the Spanish Society for Microbiology (2019): 369-376
AGEs Induce Apoptosis in Rat Osteoblast Cells by Activating the Caspase-3 Signaling Pathway Under a High-Glucose Environment In Vitro.
Authors: Liu, Jiaqiang and Mao, Jing and Jiang, Yi and Xia, Lunguo and Mao, Lixia and Wu, Yong and Ma, Pan and Fang, Bing
Journal: Applied biochemistry and biotechnology (2016): 1015-27
Cleavage of the calpain inhibitor, calpastatin, during postmortem ageing of beef skeletal muscle.
Authors: Huang, Feng and Huang, Ming and Zhang, Hong and Guo, Bing and Zhang, Dequan and Zhou, Guanghong
Journal: Food chemistry (2014): 1-6
Increased activity of cell surface peptidases in HeLa cells undergoing UV-induced apoptosis is not mediated by caspase 3.
Authors: Piva, Terrence J and Davern, Catherine M and Hall, Paula M and Winterford, Clay M and Ellem, Kay A O
Journal: International journal of molecular sciences (2012): 2650-75
Lysosomal membrane permeabilization is an early event in Sigma-2 receptor ligand mediated cell death in pancreatic cancer.
Authors: Hornick, John R and Vangveravong, Suwanna and Spitzer, Dirk and Abate, Carmen and Berardi, Francesco and Goedegebuure, Peter and Mach, Robert H and Hawkins, William G
Journal: Journal of experimental & clinical cancer research : CR (2012): 41
Page updated on November 20, 2024

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Catalog Number13303
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Physical properties

Molecular weight

668.67

Solvent

DMSO

Storage, safety and handling

H-phraseH303, H313, H333
Hazard symbolXN
Intended useResearch Use Only (RUO)
R-phraseR20, R21, R22

Storage

Freeze (< -15 °C); Minimize light exposure
UNSPSC12171501