XFD488 Anti-human/ non-human primates CD89 Antibody *A59, XFD488 Same Structure to Alexa Fluor™ 488*

The A59 monoclonal antibody binds with human/ non-human primates CD89, a 55 - 100 kD single-pass type I membrane protein often expressed on the surface of macrophages, eosinophils and neutrophils. CD89 acts in critical cellular pathways, in particular, the Fc receptor signaling pathway. Furthermore, in certain organisms, it upregulates neutrophil apoptotic process and is a promoter of oxidative stress-induced cell death. From a research standpoint, it is of biological interest due to its association with important macromolecules/ligands such as IgA2 and IgA1. CD89 is a relatively rare antibody target, with fewer than 500 publications in the last decade. Even still, CD89 is essential for immunology research, often serving as a phenotypic marker for differentiating cell types in flow cytometric applications. This antibody was purified through affinity chromatography and conjugated to XFD488 (ex/em = 499/520 nm). XFD488 is manufactured by AAT Bioquest, and it has the same chemical structure of Alexa Fluor® 488 (Alexa Fluor® is the trademark of ThermoFisher). It is compatible with the 488 nm laser and 530/30 nm bandpass filter (for example, as in the Agilent Technologies NovoCyte).

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