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Thioflavin S *CAS 1326-12-1*

Thioflavin S is a mixture of compounds that results from the methylation of dehydrothiotoluidine with sulphonic acid. It is also used to stain Alzheimer's plaques as ThT.

Spectrum

Product family

NameExcitation (nm)Emission (nm)
Thioflavin T349454

Citations

View all 13 citations: Citation Explorer
Post-stroke hippocampal neurogenesis is impaired by microvascular dysfunction and PI3K signaling in cerebral amyloid angiopathy
Authors: Osborne, Olivia M and Daftari, Manav and Naranjo, Oandy and Johar, Adarsh N and Brooks, Samantha and Colbert, Brett M and Torices, Silvia and Lewis, Elizabeth and Sendaydiego, Jet and Drexler, Gillian and others,
Journal: Cell Reports (2024)
Terahertz Irradiation Improves Cognitive Impairments and Attenuates Alzheimer’s Neuropathology in the APPSWE/PS1DE9 Mouse: A Novel Therapeutic Intervention for Alzheimer’s Disease
Authors: Zhang, Jun and Chen, Yixin and Zhao, Yarui and Wang, Panpan and Ding, Hongbin and Liu, Cong and Lyu, Junhong and Le, Weidong
Journal: Neuroscience Bulletin (2023): 1--15
SYK coordinates neuroprotective microglial responses in neurodegenerative disease
Authors: Ennerfelt, Hannah and Frost, Elizabeth L and Shapiro, Daniel A and Holliday, Coco and Zengeler, Kristine E and Voithofer, Gabrielle and Bolte, Ashley C and Lammert, Catherine R and Kulas, Joshua A and Ulland, Tyler K and others,
Journal: Cell (2022): 4135--4152
Ube2c-inhibition alleviated amyloid pathology and memory deficits in APP/PS1 mice model of AD
Authors: Li, Tian and Su, Qiang and Zhang, Zhina and Zhang, Yanli and Yang, Mingxuan and Wang, Zhuoran and Guo, Junhong and Wang, Zhaojun and Wu, Meina and Cai, Hongyan and others,
Journal: Progress in Neurobiology (2022): 102298
Trichostatin A ameliorates Alzheimer's disease-related pathology and cognitive deficits by increasing albumin expression and A$\beta$ clearance in APP/PS1 mice
Authors: Su, Qiang and Li, Tian and He, Pei-Feng and Lu, Xue-Chun and Yu, Qi and Gao, Qi-Chao and Wang, Zhao-Jun and Wu, Mei-Na and Yang, Dan and Qi, Jin-Shun
Journal: Alzheimer's Research \& Therapy (2021): 1--15

References

View all 28 references: Citation Explorer
Methods for enhancing the accuracy and reproducibility of Congo red and thioflavin T assays
Authors: Eisert R, Felau L, Brown LR.
Journal: Anal Biochem (2006): 144
Lipophilic analogs of thioflavin S as novel amyloid-imaging agents
Authors: Wu C, Cai L, Wei J, Pike VW, Wang Y.
Journal: Curr Alzheimer Res (2006): 259
Oligo(ethylene glycol) derivatives of Thioflavin T as inhibitors of protein-amyloid interactions
Authors: Inbar P, Li CQ, Takayama SA, Bautista MR, Yang J.
Journal: Chembiochem (2006): 1563
Mechanism of thioflavin T accumulation inside cells overexpressing P-glycoprotein or multidrug resistance-associated protein: role of lipophilicity and positive charge
Authors: Darghal N, Garnier-Suillerot A, Salerno M.
Journal: Biochem Biophys Res Commun (2006): 623
Characteristics of the binding of thioflavin S to tau paired helical filaments
Authors: Santa-Maria I, Perez M, Hern and ez F, Avila J, Moreno FJ.
Journal: J Alzheimers Dis (2006): 279
Page updated on November 21, 2024

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Physical properties

Molecular weight

N/A

Solvent

DMSO

Spectral properties

Absorbance (nm)

204

Excitation (nm)

391

Emission (nm)

428

Storage, safety and handling

H-phraseH303, H313, H333
Hazard symbolXN
Intended useResearch Use Only (RUO)
R-phraseR20, R21, R22

Storage

Freeze (< -15 °C); Minimize light exposure
UNSPSC12352200

CAS

1326-12-1
The staining of Thioflavin S (in green) on adjacent sections of the hippocampus of a patient suffering from&nbsp;Alzheimer's disease. Thioflavin S binds both&nbsp;senile plaques&nbsp;(SP) and&nbsp;neurofibrillary tangles&nbsp;(NFT), the two characteristic cortical lesions of Alzheimer's. Amyloid beta is a peptide derived from the&nbsp;amyloid precursor protein&nbsp;which is only found in senile plaques, and so only plaques are visible in the right hand image.
The staining of Thioflavin S (in green) on adjacent sections of the hippocampus of a patient suffering from&nbsp;Alzheimer's disease. Thioflavin S binds both&nbsp;senile plaques&nbsp;(SP) and&nbsp;neurofibrillary tangles&nbsp;(NFT), the two characteristic cortical lesions of Alzheimer's. Amyloid beta is a peptide derived from the&nbsp;amyloid precursor protein&nbsp;which is only found in senile plaques, and so only plaques are visible in the right hand image.
The staining of Thioflavin S (in green) on adjacent sections of the hippocampus of a patient suffering from&nbsp;Alzheimer's disease. Thioflavin S binds both&nbsp;senile plaques&nbsp;(SP) and&nbsp;neurofibrillary tangles&nbsp;(NFT), the two characteristic cortical lesions of Alzheimer's. Amyloid beta is a peptide derived from the&nbsp;amyloid precursor protein&nbsp;which is only found in senile plaques, and so only plaques are visible in the right hand image.