Purified Mouse Anti-human Tenascin Antibody *T2H5, monoclonal*

Tenascin (TN) is a 280 kDa protein that can be expressed in the basement membrane, perisynaptic extracellular matrix and extracellular region of cells. It is sometimes called myotendinous antigen, tenascin-C and cytotactin. In humans, TN recognizes syndecan. It upregulates cell population proliferation and gene expression, but it also is a repressor of cell adhesion. TN plays an important role in organismal processes, for instance, mesenchymal-epithelial cell signaling involved in prostate gland development, osteoblast differentiation and extracellular matrix organization. Sequencing of TN has demonstrated it contains 31 conserved structural units: EGF-like 1, EGF-like 2, EGF-like 3, EGF-like 4, EGF-like 5, EGF-like 6, EGF-like 7, EGF-like 8, EGF-like 9, EGF-like 10, EGF-like 11, EGF-like 12, EGF-like 13, EGF-like 14, EGF-like 15, Fibronectin type-III 1, Fibronectin type-III 2, Fibronectin type-III 3, Fibronectin type-III 4, Fibronectin type-III 5, Fibronectin type-III 6, Fibronectin type-III 7, Fibronectin type-III 8, Fibronectin type-III 9, Fibronectin type-III 10, Fibronectin type-III 11, Fibronectin type-III 12, Fibronectin type-III 13, Fibronectin type-III 14, Fibronectin type-III 15, and Fibrinogen C-terminal domain. TN is clinically significant because abnormalities in its function have been thought to be involved with diseases, such as autosomal dominant deafness-56 (DFNA56).

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