Purified Mouse Anti-human/non-human primates p53 Antibody *BP53-12, monoclonal*

Cellular tumor antigen p53 is a 44 kDa protein that can be located in the nucleus, mitochondrial matrix and centrosome of cells. It is sometimes referred to as Tumor suppressor p53, Phosphoprotein p53 and Antigen NY-CO-13. In Homo sapiens, cellular tumor antigen p53 has been closely linked to important functions like protein heterodimerization, DNA-binding transcription factor and histone deacetylase regulator activity. Cellular tumor antigen p53 is the subject of intensive examination stemming from the fact that it is involved with regulation of intrinsic apoptotic signaling pathway by p53 class mediator and intrinsic apoptotic signaling pathway in response to hypoxia. Cellular tumor antigen p53 aids in organismal processes, for instance, bone marrow development, cellular response to DNA damage stimulus and signal transduction by p53 class mediator, and moreover, aids in mitochondrial membrane permeability involved in apoptotic process, cell cycle G2/M phase transition and signal transduction by p53 class mediator. Cellular tumor antigen p53 downregulates transcription by RNA polymerase II and DNA-templated transcription, but also is an enhancer of pri-miRNA transcription by RNA polymerase II, cell aging and cardiac muscle cell apoptotic process. Cellular tumor antigen p53 is clinically significant because abnormalities in its function have been thought to be involved with diseases like Li-Fraumeni syndrome (LFS), lung cancer (LNCR) and bone marrow failure syndrome 5 (BMFS5). Bone marrow failure syndrome 5, an autosomal dominant inheritancedisorder characterized by delayed skeletal maturation, seizures and global developmental delay, has especially been of interest to scientists.

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