Purified Mouse Anti-human/mouse/rat SYK Antibody *SYK-01, monoclonal*

Tyrosine-protein kinase SYK (also known as Spleen tyrosine kinase or p72-Syk) is a protein with a molecular weight of 72 kDa, located in the plasma membrane, cytoplasm and nucleus of cells. In humans, tyrosine-protein kinase SYK is an integral part of organismal processes, in particular, viral process, adaptive immune response and lymph vessel development. It is the subject of comprehensive application because it plays a role in the B cell receptor signaling pathway, interleukin-3-mediated signaling pathway and stimulatory C-type lectin receptor signaling pathway. Sequencing of tyrosine-protein kinase SYK has exemplified it contains 3 types of conserved structural units: SH2 2, SH2 1 and protein kinase domain. Tyrosine-protein kinase SYK reacts with phosphatase, Toll-like receptor and protein kinase, and moreover, plays an important role in platelet activation, phagocytosis and arachidonic acid secretion. It has been thought to be involved with essential functions such as protein tyrosine kinase, protein serine/threonine kinase and non-membrane spanning protein tyrosine kinase activity.

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