Purified Mouse Anti-human/mouse/rat α/β-Tubulin dimer Antibody *TU-10, monoclonal*

Tubulin α-4A chain (sometimes referred to as Tubulin α-1 chain, Tubulin H2-α, Testis-specific α-tubulin or α-tubulin 1) is a protein with a molecular weight of 58 kDa, located in the cytoplasm and extracellular exosome of cells. In humans, tubulin α-4A chain has been closely linked to important functions such as GTPase activity. It aids in G2/M transition of mitotic cell cycle. It binds to GTP and protein kinase. It is thought to be essential to organismal processes, for instance, microtubule cytoskeleton organization, ciliary basal body-plasma membrane docking and G2/M transition of mitotic cell cycle. Mutations and abnormalities in tubulin α-4A chain have been closely linked to a number of diseases, for instance, amyotrophic lateral sclerosis 22, with or without frontotemporal dementia (ALS22). Amyotrophic lateral sclerosis 22, with or without frontotemporal dementia, an autosomal dominant inheritancedisorder characterized by amyotrophic lateral sclerosis and frontotemporal dementia, has in particular been of interest to researchers.

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