Purified Mouse Anti-human HLA-G Antibody *G233, monoclonal*

HLA class I histocompatibility antigen, α chain G is a 38 kDa transmembrane protein that can be found in the recycling endosome membrane, filopodium membrane and early endosome membrane of cells.It is alternatively called HLA G antigen and MHC class I antigen G. In humans, HLA G antigen acts to positively regulate natural killer cell cytokine production, cellular senescence and macrophage cytokine production while also represses G0 to G1 transition, angiogenesis and protein kinase B signaling. Sequencing of HLA G antigen has supported it contains 3 types of conserved structural units: Ig-like C1-type, cytoplasmic and extracellular domain. HLA G is the subject of extensive research stemming from the fact that it is involved with the immune response-inhibiting cell surface receptor signaling pathway, type I interferon signaling pathway and interferon-γ-mediated signaling pathway. It has been thought to be involved with important functions such as protein homodimerization activity. HLA G antigen binds with CD8 receptor, identical protein and signaling receptor. It is an integral part of organismal processes, for example, peripheral B cell tolerance induction, cellular defense response and protection from natural killer cell mediated cytotoxicity, and also, takes part in processes such as immune response.

Page updated on December 17, 2024