Purified Mouse Anti-human Cytokeratin 10 Antibody *VIK-10, monoclonal*

Keratin, type I cytoskeletal 10 (sometimes referred to as Cytokeratin-10, K10, CK-10 or Keratin-10) is a protein with a molecular weight of 69 kDa, located in the cornified envelope, nucleus and cytoplasm of cells. In humans, keratin-10 has been closely linked to vital functions like protein heterodimerization activity, and furthermore, sequencing of Keratin-10 has shown it contains a primary structural unit, the IF rod domain. Moreover, Keratin-10 promotes epidermis development. Keratin-10 is thought to be essential to organismal processes, namely, protein heterotetramerization, cornification and keratinocyte differentiation. Mutations and abnormalities in Keratin-10 have been associated with a number of diseases, for instance, epidermolytic hyperkeratosis (EHK), annular epidermolytic Ichthyosis (AEI) and erythroderma, ichthyosiform, congenital reticular (CRIE). Epidermolytic hyperkeratosis, a disorder characterized by erythroderma, abnormal blistering of the skin and scaling skin, has especially been of interest to researchers.

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