Purified Mouse Anti-human β2-Microglobulin Antibody *B2M-01, monoclonal, Cross Adsorbed*

β-2-Microglobulin is a 16 kDa protein that can be located in the tertiary granule lumen, extracellular exosome and recycling endosome membrane of cells. Sequencing of β-2-microglobulin has shown it contains a primary structural unit, the Ig-like C1-type domain. β-2-Microglobulin recognizes identical protein. It downregulates epithelial cell proliferation, neurogenesis and neuron projection development. But on the other hand, it also positively regulates cellular senescence, transferrin receptor binding and T cell mediated cytotoxicity. β-2-Microglobulin has been found to be involved in organismal processes, for example, modulation of age-related behavioral decline, response to molecule of bacterial origin and cellular response to iron(III) ion. β-2-Microglobulin is the subject of extensive research because of the fact that it plays a role in the interferon-γ-mediated signaling pathway. β-2-microglobulin is clinically significant because abnormalities in its function have been associated with diseases like Amyloidosis 8 (AMYL8) and Immunodeficiency 43 (IMD43). Amyloidosis 8, an autosomal dominant inheritancedisorder characterized by proteinuria, hypertensive disorder and edema, has especially been of interest to researchers.

Page updated on November 19, 2024