Purified Mouse Anti-human BCL2 Antibody *Bcl-2/100, monoclonal, Cross Adsorbed*

Apoptosis regulator Bcl-2 is a 26 kDa transmembrane protein that can be located in the cytosol, nuclear membrane and mitochondrion of cells. In Homo sapiens, apoptosis regulator Bcl-2 has been closely linked to critical functions such as protein heterodimerization activity. Apoptosis regulator Bcl-2 negatively regulates osteoblast proliferation, mitochondrial depolarization and cellular pH reduction. But it also positively regulates catalytic activity, B cell proliferation and cell population proliferation. It binds to repressing transcription factor, sequence-specific DNA and ubiquitin protein ligase. Apoptosis regulator Bcl-2 is the subject of extensive application due to the fact that it is a member of the negative regulation of intrinsic apoptotic signaling pathway, extrinsic apoptotic signaling pathway via death domain receptors and cytokine-mediated signaling pathway. Apoptosis regulator Bcl-2 takes part in processes such as organismal processes, for example, T cell differentiation in thymus, response to UV-B and ovarian follicle development. It is thought to be essential to glycoprotein biosynthetic process, mitochondrial membrane potential and calcium ion transport.

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