Purified Mouse Anti-human ARAP1 Antibody *ARAP1-2, monoclonal*

Arf-GAP with ρ-GAP domain, ANK repeat and PH domain-containing protein 1 is a protein with a molecular weight of 188 kDa, located in the plasma membrane, cytosol and Golgi apparatus of cells. In Homo sapiens, Arf-GAP with ρ-GAP domain, ANK repeat and PH domain-containing protein 1 is the subject of extensive examination stemming from the fact that it is a component of the positive regulation of epidermal growth factor receptor signaling pathway. Arf-GAP with ρ-GAP domain, ANK repeat and PH domain-containing protein 1 has been associated with critical functions such as GTPase activator activity. It reacts with metal ion, phosphatidylinositol-3,4,5-trisphosphate and type 1 angiotensin receptor. Sequencing of Arf-GAP with ρ-GAP domain, ANK repeat and PH domain-containing protein 1 has shown it contains 8 conserved structural units: Arf-GAP, Ras-associating, ρ-GAP, SAM, PH 1, PH 2, PH 3, and PH 4 domain. Arf-GAP with ρ-GAP domain, ANK repeat and PH domain-containing protein 1 inhibits stress fiber assembly ,and it also upregulates GTPase activity, filopodium assembly and receptor recycling. It is an integral part of small GTPase mediated signal transduction and cellular component movement. Arf-GAP with ρ-GAP domain, ANK repeat and PH domain-containing protein 1 is an integral part of organismal processes, in particular, actin filament reorganization involved in cell cycle and signal transduction.

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