Purified Anti-human CD29 Antibody *HI29a*

The HI29a monoclonal antibody binds with human CD29, a 130 kD transmembrane protein often found on the surface of fibroblasts and platelets. CD29 is a member of essential cellular pathways, namely, the cytokine-mediated signaling pathway, integrin-mediated signaling pathway and CD40 signaling pathway. Also, it has been thought to be involved with vital biological processes like cell adhesion, especially cell adhesion mediated by integrin. In some organisms, CD29 acts to positively regulate apoptotic process, acts to positively regulate signaling receptor activity and enhances angiogenesis. From a research standpoint, it is of biological interest due to its association with critical macromolecules/ligands such as VCAM-1. CD29 is a fairly uncommon antibody target, with a little more than 7000 publications in the last decade. Even still, CD29 has been widely used in cell adhesion, cell biology and stem cells research, frequently serving as a phenotypic marker for differentiating cell types in flow cytometric applications. This antibody was purified through affinity chromatography.

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