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Psoralen MOP Succinimidyl Ester
Psoralens and their derivatives (such as 8-MOP and 4,5’8-TMP) are well known to have unique crosslinking features to DNA. However, psoralen monomers do not have sequence-specific crosslinking ability with a target DNA. Nakao et al found that 5-MOP more effectively crosslinks DNA compared to the well-known 8-MOP (https://doi.org/10.1002/cbic.202200789). Psoralen MOP Succinimidyl Ester is a 5-MOP derivative. It is an excellent building block for preparing MOP-labeled oligos from the readily available amino-modified oligos. The 5-MOP-conjugated oligonucleotides can be used for sequence-specific crosslinking with a target DNA, thus enabling the application of psoralen-conjugated molecules in gene transcription inhibition, gene knockout, and other genomic applications. Psoralen MOP Succinimidyl Ester may also be used for preparing site-specific DNA/RNA probes via the conjugations with amino-containing biomolecules such as antibodies.
References
View all 49 references: Citation Explorer
Protective effects of 8-MOP on blood-brain barrier via the Nrf-2/HO-1 pathway in mice model of cerebral infarction.
Authors: Liu, C and Zhong, L and Tian, X-L and Han, Y-C
Journal: European review for medical and pharmacological sciences (2018): 4278-4287
Authors: Liu, C and Zhong, L and Tian, X-L and Han, Y-C
Journal: European review for medical and pharmacological sciences (2018): 4278-4287
The anti-metastatic effect of 8-MOP on hepatocellular carcinoma is potentiated by the down-regulation of bHLH transcription factor DEC1.
Authors: Xiong, Jing and Yang, Huan and Luo, Wenjing and Shan, Enfang and Liu, Jie and Zhang, Feng and Xi, Tao and Yang, Jian
Journal: Pharmacological research (2016): 121-33
Authors: Xiong, Jing and Yang, Huan and Luo, Wenjing and Shan, Enfang and Liu, Jie and Zhang, Feng and Xi, Tao and Yang, Jian
Journal: Pharmacological research (2016): 121-33
Cytochrome P450 CYP1B1 interacts with 8-methoxypsoralen (8-MOP) and influences psoralen-ultraviolet A (PUVA) sensitivity.
Authors: Deeni, Yusuf Y and Ibbotson, Sally H and Woods, Julie A and Wolf, C Roland and Smith, Gillian
Journal: PloS one (2013): e75494
Authors: Deeni, Yusuf Y and Ibbotson, Sally H and Woods, Julie A and Wolf, C Roland and Smith, Gillian
Journal: PloS one (2013): e75494
Establishment of mus skin photo-damage model by 8-MOP plus UVA irradiation.
Authors: Liang, Hong and Li, Jiawen and Zhang, Li
Journal: Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen (2007): 742-4
Authors: Liang, Hong and Li, Jiawen and Zhang, Li
Journal: Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen (2007): 742-4
Antigenotoxic effects of three essential oils in diploid yeast (Saccharomyces cerevisiae) after treatments with UVC radiation, 8-MOP plus UVA and MMS.
Authors: Bakkali, F and Averbeck, S and Averbeck, D and Zhiri, A and Baudoux, D and Idaomar, M
Journal: Mutation research (2006): 27-38
Authors: Bakkali, F and Averbeck, S and Averbeck, D and Zhiri, A and Baudoux, D and Idaomar, M
Journal: Mutation research (2006): 27-38
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